I use two SIM cards in my FP2, the same as before in the FP1 for many years. The primary one in slot 1, the second card only if I would have signal problems or similar (but both using the O2 network).
On the Fairphone 2, you can only set one SIM card slot to 4G or 3G, the other one will then be restricted to 2G. It’s a hardware limitation, nothing to do with reception or any technical difference in the SIM slots.
Which is not to say that any particular SIM slot would be unable to develop a malfunction. It’s still possible that one slot works better than the other.
If you set one of the SIM cards as 3G or 4G, you MUST set the other SIM as 2G.
→ do I have to really change the default setting “LTE (preferred”) for my formerly primary card, now in slot 2, to “2G”? – Or “Wurscht”, as you would say in German?